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Case ID: 188

Publication date: 22 Dec, 2024

Consensus grade: Reactive atypia

User Diagnosis Difficulty Comment
Pathologist 1 Reactive atypia Typical
Pathologist 2 Reactive atypia Typical
Pathologist 3 Reactive atypia Typical
Pathologist 4 Reactive atypia Typical
Pathologist 5 Reactive atypia Typical
Pathologist 6 Carcinoma in situ (CIS) Borderline lower
Pathologist 7 Reactive atypia Typical
Pathologist 8 Reactive atypia Typical

superficial cells

Pathologist 9 Reactive atypia Typical
Pathologist 10 Reactive atypia Typical
Pathologist 11 Reactive atypia Typical
Pathologist 12 Reactive atypia Borderline higher
Pathologist 13 Reactive atypia Typical
Pathologist 14 Reactive atypia Typical
Pathologist 15 Reactive atypia Typical

No specific comment.

Pathologist 16 Reactive atypia Bordering on higher
Pathologist 17 Reactive atypia Bordering on lower
Pathologist 18 Reactive atypia Bordering on higher
Pathologist 19 Reactive atypia Typical
Pathologist 20 Reactive atypia Bordering on higher
Pathologist 21 Reactive atypia Typical
Pathologist 22 Reactive atypia Typical


Case description (by case creator):

The main change here is ‘degenerative’ nuclear atypia in a rather unusually prominent umbrella cell layer. The underlying urothelium shows mild reactive changes in places with some chronic inflammation in the lamina propria.