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Case ID: 381

Publication date: 22 Dec, 2024

Consensus grade: Carcinoma in situ (CIS)

User Diagnosis Difficulty Comment
Pathologist 1 Carcinoma in situ (CIS) Typical
Pathologist 2 Carcinoma in situ (CIS) Typical
Pathologist 3 Atypia/dysplasia Borderline higher
Pathologist 4 Carcinoma in situ (CIS) Typical
Pathologist 5 Carcinoma in situ (CIS) Typical
Pathologist 6 Carcinoma in situ (CIS) Typical
Pathologist 7 Carcinoma in situ (CIS) Typical
Pathologist 8 Carcinoma in situ (CIS) Typical
Pathologist 9 Carcinoma in situ (CIS) Typical
Pathologist 10 Carcinoma in situ (CIS) Typical
Pathologist 11 Carcinoma in situ (CIS) Typical
Pathologist 12 Carcinoma in situ (CIS) Typical
Pathologist 13 Carcinoma in situ (CIS) Typical
Pathologist 14 Carcinoma in situ (CIS) Typical
Pathologist 15 Carcinoma in situ (CIS) Typical

No specific comment.

Pathologist 16 Carcinoma in situ (CIS) Borderline lower

would use IHCH to verify, could also be reactive

Pathologist 17 Carcinoma in situ (CIS) Typical
Pathologist 18 Carcinoma in situ (CIS) Typical
Pathologist 19 Carcinoma in situ (CIS) Typical


Case description (by case creator):

Lesion shows marked variation in nuclear size, shape and chromatin. Architecturally, cells appear irregularly clustered and the epithelium is disorganized.