K22 | Prostate cancer grading

Case ID: 281

Publication date: 20 Dec, 2024

Consensus grade: GS 3+4=7 (ISUP 2)

User	Diagnosis	Difficulty	Comment
Pathologist 1	GS 3+4=7 (ISUP 2)	Borderline higher	Glands crowded but also focally fused
Pathologist 2	GS 3+4=7 (ISUP 2)	Typical
Pathologist 3	GS 3+4=7 (ISUP 2)	Typical
Pathologist 4	GS 3+4=7 (ISUP 2)	Typical
Pathologist 5	GS 3+4=7 (ISUP 2)	Borderline lower	one could also discuss a Score 6, but there is some glomerulation and congfluence
Pathologist 6	GS 3+4=7 (ISUP 2)	Borderline lower
Pathologist 7	GS 3+3=6 (ISUP 1)	Borderline higher	No convincing fusion of poorly formed glands.
Pathologist 8	GS 3+3=6 (ISUP 1)	Borderline higher
Pathologist 9	GS 3+4=7 (ISUP 2)	Typical
Pathologist 10	GS 4+3=7 (ISUP 3)	Typical
Pathologist 11	GS 4+3=7 (ISUP 3)	Typical
Pathologist 12	GS 3+4=7 (ISUP 2)	Typical
Pathologist 13	GS 3+4=7 (ISUP 2)	Borderline higher
Pathologist 14	GS 3+3=6 (ISUP 1)	Typical	3 with typical tangential cut
Pathologist 15	GS 3+4=7 (ISUP 2)	Typical
Pathologist 16	GS 4+3=7 (ISUP 3)	Borderline higher	Difficult to judge percentages on images sometimes when Gleason grade 3 predominates in some and grade 4 is more prevalent in others, therefore also strongly considered 3 + 4.
Pathologist 17	GS 3+4=7 (ISUP 2)	Typical	Mainly single glands. Some fused and poorly formed glands also
Pathologist 18	GS 3+3=6 (ISUP 1)	Borderline higher
Pathologist 19	GS 3+4=7 (ISUP 2)	Borderline higher
Pathologist 20	GS 3+4=7 (ISUP 2)	Borderline higher
Pathologist 21	GS 3+4=7 (ISUP 2)	Borderline higher
Pathologist 22	GS 3+4=7 (ISUP 2)	Borderline higher
Pathologist 23	GS 4+3=7 (ISUP 3)	Typical
Pathologist 24	GS 3+4=7 (ISUP 2)	Typical

Case description (by case creator):

Some images only contain GP3 but there are also areas with poorly formed and fused glands justifying 347.

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