K26 | Prostate cancer grading

Case ID: 314

Publication date: 19 Apr, 2026

Consensus grade: GS 3+3=6 (ISUP 1)

User	Diagnosis	Difficulty	Comment
Pathologist 1	GS 3+3=6 (ISUP 1)	Typical
Pathologist 2	GS 3+3=6 (ISUP 1)	Typical
Pathologist 3	GS 3+3=6 (ISUP 1)	Typical
Pathologist 4	GS 3+3=6 (ISUP 1)	Typical	there are some confluent aspects, but 6 is better in my opinion
Pathologist 5	GS 3+3=6 (ISUP 1)	Typical
Pathologist 6	GS 3+3=6 (ISUP 1)	Typical
Pathologist 7	GS 3+3=6 (ISUP 1)	Borderline lower
Pathologist 8	GS 3+3=6 (ISUP 1)	Borderline higher	Some PIN-like areas
Pathologist 9	GS 3+3=6 (ISUP 1)	Typical
Pathologist 10	GS 3+3=6 (ISUP 1)	Typical
Pathologist 11	GS 3+3=6 (ISUP 1)	Typical
Pathologist 12	GS 3+3=6 (ISUP 1)	Typical
Pathologist 13	GS 3+3=6 (ISUP 1)	Typical
Pathologist 14	GS 3+3=6 (ISUP 1)	Typical
Pathologist 15	GS 3+3=6 (ISUP 1)	Typical
Pathologist 16	GS 3+3=6 (ISUP 1)	Typical	All well formed separate glands, some pseudohyperplastic
Pathologist 17	GS 3+3=6 (ISUP 1)	Typical
Pathologist 18	GS 3+3=6 (ISUP 1)	Typical
Pathologist 19	GS 3+3=6 (ISUP 1)	Typical	Some pseudohyperplastic areas. Don't think there is enough glandular fusion for pattern 4. Also a few tangentially sectioned glands.
Pathologist 20	GS 3+3=6 (ISUP 1)	Typical
Pathologist 21	GS 3+3=6 (ISUP 1)	Borderline higher
Pathologist 22	GS 3+3=6 (ISUP 1)	Typical
Pathologist 23	GS 3+3=6 (ISUP 1)	Typical
Pathologist 24	GS 3+3=6 (ISUP 1)	Typical

Case description (by case creator):

Typical 336 with only a few glands that may be thought to be somewhat poorly formed. Not enough for GP4.

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